If your site respond to urls that contain uppercase and lowercase characters (the same page responds to urls: yourdomain.com/my-Url, yourdomain.com/my-url), taking into account SEO parameters that is not good since the search engines are case-sensitive so you'd have more than one page indexed with the same content. A trick you can use is to convert all urls to lowercase, so:
Put in the server config
Centos / Fedora / RHEL: /etc/httpd/conf/httpd.conf
Debian / Ubuntu: /etc/apache2/apache2.conf
RewriteEngine On RewriteMap lowercase int:tolower RewriteCond %{QUERY_STRING} ^$ RewriteCond %{REQUEST_URI} !.(css|js|php|[jm]pe?g|png|[yx]ml| json|gif|ico|pdf|swf|html|flv|doc|pps|rar|zip|eps| odt|wmv|avi|tar(.(bz|gz))?|gz)$ RewriteCond %{REQUEST_URI} ^.*[A-Z].*$ RewriteCond %{HTTP_HOST} ^(.*)$ RewriteRule ^(.*)$ http://%1${lowercase:$1} [L]
Note that the first condition excludes all URLs that contain parameters and the second all URLs that make requests to images, pdf, doc, flash, other
Then in each virtual host
RewriteEngine On RewriteOptions Inherit